This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

XI. Furosemide-Inhibitable Fluid Absorption Across Retinal Pigment Epithelium In Vivo

Shunji Tsuboi, MD; Jonathan E. Pederson, MD

Arch Ophthalmol. 1986;104(4):602-603.

Abstract
• Rhegmatogenous retinal detachments were created in one eye of each of six cynomolgus monkeys. Total vitrectomy alone was performed in the fellow eyes. The rate of disappearance of fluorescein sodium injected into the vitreous cavity was measured with kinetic vitreous fluorophotometry. Intravitreal 10^–4M probenecid was used to inhibit active outward transport of fluorescein. In eyes with retinal detachment, the rate of fluorescein loss from the vitreous cavity was decreased 44% and 22% following intravitreal injection of 10^–4 and 10^–5M furosemide (Lasix), respectively. Intravitreal 10^–4M furosemide decreased the rate of fluorescein loss in fellow eyes by 35%. The rate of fluorescein loss via the anterior chamber accounted for only 1% to 8% of the total rate of vitreous fluorescein loss. Thus, it is concluded that intravitreal furosemide decreases the rate of fluid absorption across the retinal pigment epithelium.

Author Affiliations
From the Department of Ophthalmology, University of Minnesota, Minneapolis.

Footnotes
Accepted for publication Jan 7, 1986.

Reprint requests to Box 493 Mayo, University of Minnesota, Minneapolis, MN 55455 (Dr Pederson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Partial resolution of diabetic macular oedema after systemic treatment with furosemide
Ciardella
Br J Ophthalmol 2004;88:1224-1225.
FULL TEXT