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Makoto Araie, MD

Arch Ophthalmol. 1986;104(3):435-438.

Abstract
• I studied the in vitro effect of three intraocular irrigating solutions—a glutathione bicarbonate Ringer (GBR), a commercially available glucose glutathione bicarbonate solution (BSS Plus), and a citrate-acetate bicarbonate solution (S-MA₂)—on the barrier function of the corneal endothelium. The major chemical differences between S-MA₂ and GBR or BSS Plus are that S-MA₂ does not contain glutathione and phosphate but does contain acetate and citrate. Paired rabbit corneas were perfused separately, and the endothelial permeability (P_ac) to carboxyfluorescein was determined. Between the paired corneas perfused with GBR and BSS Plus, there was no significant difference in the P_ac, while a significant difference in this factor was seen between the paired corneas perfused with GBR and S-MA₂; the figure was about 20% larger for S-MA₂. It is suggested that BSS Plus or GBR is less harmful to the endothelial barrier function than S-MA₂ and that P_ac to carboxyfluorescein can be a useful index in determining the safety of the intraocular irrigating solutions.

Author Affiliations
From the Division of Ophthalmology, Stanford (Calif) University School of Medicine. Dr Araie is now with the University of Tokyo School of Medicine.

Footnotes
Accepted for publication Nov 6, 1985.

Reprint requests to the Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1, Hongo, Bunkyo-ku, 113 Tokyo, Japan (Dr Araie).

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