Intravitreous fibronectin and platelet-derived growth factor. New model for traction retinal detachment
J. H. Yeo, J. Sadeghi, P. A. Campochiaro, W. R. Green and B. M. Glaser
In proliferative vitreoretinopathy and trauma, traction retinal detachments
result from cellular migration into the vitreous cavity with contractile
membrane formation. Cleary and Ryan have established the efficacy of
intravitreous injection of autologous blood in reproducing this pathologic
process in the rabbit eye. It has previously been shown that two serum
components, fibronectin and platelet-derived growth factor, stimulate
cellular migration. We now show that contractile membranes and traction
retinal detachments occur in 72% of rabbit eyes within three weeks
following intravitreous injection of fibronectin and platelet-derived
growth factor. These results provide a straightforward new model to study
the development of intravitreous cellular membranes and traction retinal
detachments.