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Peter A. Campochiaro, MD; Bert M. Glaser, MD

Arch Ophthalmol. 1986;104(2):277-280.

Abstract
• Retinal pigment epithelial (RPE) cell chemotaxis may play an important role in proliferative vitreoretinopathy (PVR). Fibronectin and platelet-derived growth factor are chemoattractants for RPE cells. In this study, we used these chemoattractants to examine mechanisms involved in RPE cell chemotaxis. Our results demonstrate that inhibition of RNA and protein synthesis, but not DNA synthesis, are associated with reduced chemotaxis. Microtubules and microfilaments are involved since cytochalasin B and colchicine are potent inhibitors of RPE cell migration. Dexamethasone, to which a beneficial effect has been attributed in an animal model of PVR, had no effect on RPE cell migration. Information concerning mechanisms involved in RPE cell migration may help to explore new avenues of treatment in PVR.

Author Affiliations
From the Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville (Dr Campochiaro); and the Center for Vitreoretinal Research, Wilmer Ophthalmological Institute, The Johns Hopkins Hospital, Baltimore (Dr Glaser).

Footnotes
Accepted for publication Aug 15,1985.

Reprint requests to Department of Ophthalmology, Box 475, University of Virginia School of Medicine, Charlottesville, VA 22908 (Dr Campochiaro).

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