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Shigeto Hirose, MD; Toichiro Kuwabara, MD; Robert B. Nussenblatt, MD; Barbara Wiggert, PhD; T. Michael Redmond, PhD; Igal Gery, PhD

Arch Ophthalmol. 1986;104(11):1698-1702.

Abstract
• Interphotoreceptor retinoid-binding protein was found to be highly uveitogenic in primates. All six monkeys immunized with bovine interphotoreceptor retinoid-binding protein developed ocular inflammation. The main clinical changes were sheathing of retinal vessels and deep well-circumscribed yellow-white lesions. Histologic changes in the retina included shortening of the outer segments and foci of inflammation, which extended through all retinal layers. Particularly profound were the choroidal changes, such as severe inflammatory infiltration, which often formed focal granulomas with epithelioid and giant cells. Some granulomas had the structure of Dalen-Fuchs nodules. These structures and other histologic changes in the monkeys closely resemble those in uveitic conditions in humans, such as sympathetic ophthalmia or Vogt-Koyanagi-Harada syndrome. These findings show that antigen that localizes specifically in the retina may initiate an immunopathogenic process affecting mainly the choroid.

Author Affiliations
From the Laboratories of Immunology (Drs Hirose, Nussenblatt, and Gery), Ophthalmic Pathology (Dr Kuwabara), and Retinal Cell and Molecular Biology (Drs Wiggert and Redmond), National Eye Institute, National Institutes of Health, Bethesda, Md.

Footnotes
Accepted for publication May 22, 1986.

Reprint requests to Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bldg 10, Room 10N210, Bethesda, MD 20892 (Dr Hirose).

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