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Michael F. Marmor, MD; Akira Negi, MD

Arch Ophthalmol. 1986;104(11):1674-1677.

Abstract
• We studied in the rabbit the effects of pharmacologic agents on the absorption of Hanks' solution from the subretinal space of experimental nonrhegmatogenous detachments. Intravenous acetazolamide had no effect at a clinical dose (15 mg/kg) but increased the rate of fluid absorption significantly at high doses (50 mg/kg). Acetazolamide causes systemic pH to fall, while Pco₂ and Po₂ increase; however, duplicating some of these effects by artificial respiration or breathing 95% O₂ plus 5% CO₂ did not alter the rate of fluid absorption. Adding cyclic AMP and related agents to the vitreous and subretinal space slowed down fluid absorption by 25%, whereas cyclic GMP analogues increased the rate of absorption by 33%.

Author Affiliations
From the Division of Ophthalmology, Stanford (Calif) University Medical Center; and the Veterans Administration Medical Center, Palo Alto, Calif. Dr Negi is now with Kyoto University, Kyoto, Japan.

Footnotes
Accepted for publication May 2, 1986.

Reprint requests to Division of Ophthalmology, Stanford University Medical Center, Stanford, CA 94305 (Dr Marmor).

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