Pharmacologic modification of subretinal fluid absorption in the rabbit eye
M. F. Marmor and A. Negi
We studied in the rabbit the effects of pharmacologic agents on the
absorption of Hanks' solution from the subretinal space of experimental
nonrhegmatogenous detachments. Intravenous acetazolamide had no effect at a
clinical dose (15 mg/kg) but increased the rate of fluid absorption
significantly at high doses (50 mg/kg). Acetazolamide causes systemic pH to
fall, while PCO2 and PO2 increase; however, duplicating some of these
effects by artificial respiration or breathing 95% O2 plus 5% CO2 did not
alter the rate of fluid absorption. Adding cyclic AMP and related agents to
the vitreous and subretinal space slowed down fluid absorption by 25%,
whereas cyclic GMP analogues increased the rate of absorption by 33%.
