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Correlation Between Survival Time and Cytomorphometry of Primary Tumors

Larry A. Donoso, MD, PhD; James J. Augsburger, MD; Jerry A. Shields, MD; Richard A. Greenberg, PhD; John Gamel, MD

Arch Ophthalmol. 1986;104(1):76-78.

Abstract
• The length of survival time following enucleation was determined for 29 patients with primary malignant melanoma of the choroid and ciliary body who subsequently died of metastatic disease. Histologic sections of the 29 tumors were studied by standard light microscopic techniques and computerized morphometry. The largest diameter of each tumor was measured on the 37% formaldehydefixed, paraffin-embedded slides; a cell type was assigned to each tumor on the basis of histologic study, using the modified Callender cell-type classification system; and inverse standard deviation of the nucleolar area (ISDNA) was determined for each tumor by computerized morphometric analysis. The observed deathorder of these patients was then compared with the death-order predicted by ranking cases in ascending order of age at treatment, size of tumor, cell type, and ISDNA. Using rank-order correlation coefficient tests, only the correlation between ISDNA rank-order and observed deathorder was found to be statistically significant. We believe that the limitations of the modified Callender cell-type classification system in predicting length of survival time following enucleation are related to the relatively few categories (four) in which to classify tumors, whereas the ISDNA represents a continuous spectrum of unlimited categories. As such, ISDNA can be more discriminant in selecting tumors of high malignant potential.

Author Affiliations
From the Department of Clinical Research, the Retina Service, and the Ocular Oncology Service, Wills Eye Hospital, Philadelphia (Drs Donoso, Augsburger, and Shields) and the Departments of Community Health (Dr Greenberg) and Ophthalmology (Dr Gamel), University of Louisville.

Footnotes
Accepted for publication Aug 5, 1985.

Reprint requests to Wills Eye Hospital, Research Division, Ninth and Walnut streets, Philadelphia, PA 19107 (Dr Donoso).

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