Abnormal retinal function associated with fenretinide, a synthetic retinoid

M. I. Kaiser-Kupfer, G. L. Peck, R. C. Caruso, M. J. Jaffe, J. J. DiGiovanna and E. G. Gross

Five patients with basal cell carcinoma received fenretinide. Two patients while receiving the drug had evidence of abnormal rod photoreceptor function that reversed rapidly on cessation of therapy. We speculate that fenretinide may interfere with the binding of vitamin A to opsin or with the transport of vitamin A.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Does use of isotretinoin rule out a career in flying?
Mollan et al.
Br. J. Ophthalmol. 2006;90:957-959.
ABSTRACT | FULL TEXT  

Phase I Trial of Oral Fenretinide in Children With High-Risk Solid Tumors: A Report From the Children's Oncology Group (CCG 09709)
Villablanca et al.
JCO 2006;24:3423-3430.
ABSTRACT | FULL TEXT  

Phase II Study of Fenretinide (NSC 374551) in Adults With Recurrent Malignant Gliomas: A North American Brain Tumor Consortium Study
Puduvalli et al.
JCO 2004;22:4282-4289.
ABSTRACT | FULL TEXT  

Phase I Clinical Trial of Alitretinoin and Tamoxifen in Breast Cancer Patients: Toxicity, Pharmacokinetic, and Biomarker Evaluations
Lawrence et al.
JCO 2001;19:2754-2763.
ABSTRACT | FULL TEXT  

Retinoid Metabolism in the Prostate: Effects of Administration of the Synthetic Retinoid N-(4-Hydroxyphenyl)retinamide
Lewis and Hochadel
Cancer Res. 1999;59:5947-5955.
ABSTRACT | FULL TEXT  

Effects of Fenretinide (4-HPR) on Dark Adaptation
Caruso et al.
Arch Ophthalmol 1998;116:759-763.
ABSTRACT | FULL TEXT