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The Efficacy of Cyclosporine and Corticosteroids in Treatment

Gerald Striph, MD; Bernard Doft, MD; Bruce Rabin, MD, PhD; Bruce Johnson, MD

Arch Ophthalmol. 1986;104(1):114-117.

Abstract
• This study compares the efficacy of cyclosporine and corticosteroids in the treatment of retina S antigen-induced uveitis (experimental autoimmune uveitis). Forty guinea pigs were immunized with retina S antigen in complete Freund's adjuvant to induce uveitis. After 16 days, animals were divided into groups that received a two-week course of daily intramuscular injections of cyclosporine, corticosteroids, both drugs, or saline. Eyes were graded by a masked retinal specialist for amount of vitreous cells by biomicroscopy, and after enucleation by a masked ocular pathologist for histologic evidence of inflammation. Clinically and histopathologically, animals treated with cyclosporine, or cyclosporine and corticosteroids, had statistically significant reduction of intraocular inflammation compared with controls. Corticosteroids alone had a less beneficial effect. The combined use of cyclosporine and corticosteroids, at the single dose tested, did not demonstrate synergism.

Author Affiliations
From the Retina-Vitreous Consultants (Dr Doft) and the Departments of Ophthalmology (Drs Doft and Striph) and Pathology (Drs Johnson and Rabin), University of Pittsburgh School of Medicine and Eye and Ear Hospital. Dr Striph is now with the Department of Ophthalmology, Washington University Medical Center, St Louis.

Footnotes
Accepted for publication Sept 9, 1985.

Presented in part as a scientific exhibition at the annual meeting of the American Academy of Ophthalmology, Atlanta, Nov 11-15, 1984.

Reprint requests to Retina-Vitreous Consultants, Eye and Ear Hospital, 230 Lothrop St, Pittsburgh, PA 15213 (Dr Doft).

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ABSTRACT