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  Vol. 103 No. 9, September 1985 TABLE OF CONTENTS
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Fluorouracil (5-FU) and Cytarabine (Ara-C) Inhibition of Corneal Epithelial Cell and Conjunctival Fibroblast Proliferation

Kim S. Mallick, MD; Anthony S. Hajek, PhD; Richard K. Parrish II, MD

Arch Ophthalmol. 1985;103(9):1398-1402.


Abstract



• We evaluated the antiproliferative properties of fluorouracil (5-FU) and cytarabine (ara-C) in a tissue culture model of rabbit corneal epithelial cells and conjunctival fibroblasts. Cells were treated with fluorouracil or cytarabine for five days. Corneal epithelial cell proliferation was inhibited to 50% of control proliferation by 0.6 mg/L of fluorouracil or 30 µg/L of cytarabine. Proliferation of conjunctival fibroblasts was inhibited to 50% of control by 0.5 mg/L of fluorouracil or 50 µg/L of cytarabine. The antiproliferative effect of 10 mg/L of fluorouracil was not blocked by thymidine. The inhibition of proliferation produced by 100 or 1,000 µg/L of cytarabine was blocked by 2'-deoxycytidine at concentrations of 10–5M and 10–4M, respectively. The antiproliferative effects of fluorouracil and cytarabine appear similar for both cell types. Blockage of cytarabine-related ocular toxic effects may be possible with 2'-deoxycytidine.



Author Affiliations



From the Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine.


Footnotes



Accepted for publication April 2, 1985.

Reprint requests to Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, PO Box 016880, Miami, FL 33101 (Dr Parrish).



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