Fluorouracil (5-FU) and Cytarabine (Ara-C) Inhibition of Corneal Epithelial Cell and Conjunctival Fibroblast Proliferation

doi:10.1001/archopht.1985.01050090150052

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Vol. 103 No. 9, September 1985

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Fluorouracil (5-FU) and Cytarabine (Ara-C) Inhibition of Corneal Epithelial Cell and Conjunctival Fibroblast Proliferation

Kim S. Mallick, MD; Anthony S. Hajek, PhD; Richard K. Parrish II, MD

Arch Ophthalmol. 1985;103(9):1398-1402.

Abstract

• We evaluated the antiproliferative properties of fluorouracil(5-FU) and cytarabine (ara-C) in a tissue culture model of rabbitcorneal epithelial cells and conjunctival fibroblasts. Cellswere treated with fluorouracil or cytarabine for five days.Corneal epithelial cell proliferation was inhibited to 50% ofcontrol proliferation by 0.6 mg/L of fluorouracil or 30 µg/Lof cytarabine. Proliferation of conjunctival fibroblasts wasinhibited to 50% of control by 0.5 mg/L of fluorouracil or 50µg/L of cytarabine. The antiproliferative effect of 10mg/L of fluorouracil was not blocked by thymidine. The inhibitionof proliferation produced by 100 or 1,000 µg/L of cytarabinewas blocked by 2'-deoxycytidine at concentrations of 10^–5Mand 10^–4M, respectively. The antiproliferative effectsof fluorouracil and cytarabine appear similar for both celltypes. Blockage of cytarabine-related ocular toxic effects maybe possible with 2'-deoxycytidine.

Author Affiliations

From the Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine.

Footnotes

Accepted for publication April 2, 1985.

Reprint requests to Bascom Palmer Eye Institute, Departmentof Ophthalmology, University of Miami School of Medicine, POBox 016880, Miami, FL 33101 (Dr Parrish).

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