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A Clinical Hypothesis Based on the Myotoxicity of Local Anesthetics

Edgar A. Rainin, MD; Bruce M. Carlson, MD, PhD

Arch Ophthalmol. 1985;103(9):1337-1339.

Abstract
• Postoperative diplopia and ptosis can be temporary or permanent complications in patients who have undergone ophthalmic surgery while under local anesthesia. We encountered six patients with such complications and hypothesize that some cases of postoperative diplopia and ptosis could be attributed to myotoxic effects of local anesthetics. These effects may cause the degeneration and subsequent regeneration of muscle fibers of the levator or extraocular muscles and result in temporary or permanent muscle weakness.

Author Affiliations
From the Bay Area Eye Center, Walnut Creek, Calif (Dr Rainin), and the Departments of Anatomy and Biological Sciences, University of Michigan, Ann Arbor (Dr Carlson).

Footnotes
Accepted for publication April 16, 1985.

Reprint requests to the Department of Anatomy, 4622 Med Sci II, University of Michigan, Ann Arbor, MI 48109 (Dr Carlson).

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