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Effect of Sulindac on the Permeability of the Blood-Retinal Barrier in Early Diabetic Retinopathy
Jose G. Cunha-Vaz, MD, PhD;
Carolina C. Mota, DPh;
Eugenio C. Leite, MD;
Jose R. Abreu, MD;
Manuel A. Ruas, MD
Arch Ophthalmol. 1985;103(9):1307-1311.
Abstract
• To study the effect of sulindac on the alteration of the blood-retinal barrier, 24 insulin-dependent diabetic patients with minimal or no retinopathy were randomly assigned to receive either oral sulindac (200 mg twice daily) or a placebo for a period of six months. All patients underwent fundus photography, fluorescein angiography, and vitreous fluorophotometry before treatment and after 1, 3, and 6 months of treatment. Vitreous fluorophotometry data showed that there were fewer alterations of the blood-retinal barrier in the sulindac group compared with the placebo group during the six-month study period.
Author Affiliations
From the Department of Ophthalmology, University of Illinois School of Medicine, Chicago (Dr Cunha-Vaz), and the Departments of Ophthalmology (Drs Mota, Leite, and Abreu) and Endocrinology (Dr Ruas), Coimbra (Portugal) University.
Footnotes
Accepted for publication May 7, 1985.
Reprint requests to the University of Illinois Eye and Ear Infirmary, 1855 W Taylor St, Chicago, IL 60612 (Dr Cunha-Vaz).
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