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Joseph Caprioli, MD; George L. Spaeth, MD

Arch Ophthalmol. 1985;103(8):1145-1149.

Abstract
• The optic nerves of 34 eyes of 34 patients with low-tension glaucoma were compared with those of 41 eyes of 41 patients with high-tension glaucoma. Mean intraocular pressure in the low-tension group was 16.9 ± 0.7 mm Hg (mean ± SEM) compared with 31.7 ± 0.8 mm Hg in the high-tension group. Mean total visual field loss was not significantly different in the two groups, as determined by computerized threshold perimetry (OCTOPUS). The optic disc rim in low-tension eyes was significantly thinner than in high-tension eyes (P =.018); the largest difference occurred inferiorly and infero-temporally (P <.001). The appearance of the optic nerve is useful to distinguish between these two subtypes of glaucoma and may be a more meaningful indicator than intraocular pressure. Our findings support the hypothesis that there are at least two different mechanisms for optic nerve damage in glaucoma.

Author Affiliations
From the William and Anna Goldberg Glaucoma Service and Research Laboratories of the Wills Eye Hospital, Philadelphia. Dr Caprioli is now with Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication April 16, 1985.

Reprint requests to the Department of Ophthalmology and Visual Science, Yale University School of Medicine, Box 3333 Cedar St, New Haven, CT 06510 (Dr Caprioli).

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