This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

J. Gass; M. Donald, MD

Arch Ophthalmol. 1985;103(7):924-931.

Abstract
• Between December 1962 and May 1979, growth of choroidal and ciliary body melanomas was documented in 34 patients prior to enucleation, and in one patient whose eye was obtained at autopsy. Melanoma growth rates in 33 of these 35 eyes were calculated and compared with mitotic index, tumor cytology, tumor size, and mortality. Each melanoma appeared to grow at a constant rate that varied widely in different melanomas. Growth rate correlated with mitotic index. Most large tumors and epithelioid and mixed cell melanomas demonstrated fast growth rates. Most melanomas causing death contained epithelioid cells and were growing rapidly. These findings do not support the conclusion of Zimmerman and colleagues that enucleation is responsible for most metastatic deaths. Rather, it argues against one of the fundamental assumptions on which their conclusion is based, namely, that all melanomas have a relatively uniform slow growth rate prior to enucleation.

Author Affiliations
From the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine.

Footnotes
Accepted for publication Feb 4, 1985.

Presented as the 45th George E. de Schweinitz Lecture, at the Section on Ophthalmology meeting of the College of Physicians of Philadelphia, Philadelphia, Nov 18, 1982.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Zimmerman-McLean-Foster hypothesis: 25 years later
Singh et al.
Br J Ophthalmol 2004;88:962-967.
ABSTRACT | FULL TEXT  

Mode of presentation and time to treatment of uveal melanoma in Finland
Eskelin and Kivela
Br J Ophthalmol 2002;86:333-338.
ABSTRACT | FULL TEXT  

Transformation of Cell Type in Uveal Melanomas: A Quantitative Histologic Analysis
Bechrakis et al.
Arch Ophthalmol 2000;118:1406-1412.
ABSTRACT | FULL TEXT  

Uveal Melanoma: Growth Rate and Prognosis
Char et al.
Arch Ophthalmol 1997;115:1014-1018.
ABSTRACT  

Melanoma Arising De Novo Over a 16-Month Period
Sahel et al.
Arch Ophthalmol 1988;106:381-385.
ABSTRACT  

Do I Take the Eye Out or Leave It In?
Manschot
Arch Ophthalmol 1986;104:1747-1748.
ABSTRACT  

Uveal Melanoma: Doubling Time and Mitotic Index
Juster and Char
Arch Ophthalmol 1986;104:174-174.
ABSTRACT  

How Should We Manage a Patient With Uveal Melanoma?
Fine
Arch Ophthalmol 1985;103:910-911.
ABSTRACT  

Comparison of Prognosis After Enucleation vs Cobalt 60 Irradiation of Melanomas
Gass
Arch Ophthalmol 1985;103:916-923.
ABSTRACT