This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Pretherapy Serum Liver Enzyme and Liver Scan Abnormalities

Larry A. Donoso, MD, PhD; David Berd, MD; James J. Augsburger, MD; Michael J. Mastrangelo, MC; Jerry A. Shields, MD

Arch Ophthalmol. 1985;103(6):796-798.

Abstract
• The liver was the organ most frequently involved in 50 patients with primary melanomas of the choroid or ciliary body, who were treated with enucleation or cobalt plaque radiotherapy and who subsequently developed systemic metastasis. Forty-seven (94%) of the patients had clinical or laboratory evidence of liver metastasis. The median survival time following treatment of the primary choroidal melanoma was 28 months (range, 7.7 to 123.1 months). Results of pretreatment studies, including serum liver enzyme levels, liver scans, or both, were abnormal in six (12%) of the patients studied. As a group, the eight patients who died within one year following ocular surgery had a significantly higher prevalence of pretreatment laboratory abnormalities. Extraocular extension of the choroidal melanoma was also present in four (50%) of these eight patients. Conversely, no patient who survived longer than the median survival period (28 months) had abnormal pretreatment laboratory findings.

Author Affiliations
From the Department of Clinical Research, Retina Service and Ocular Oncology Service, Wills Eye Hospital (Drs Donoso, Augsburger, and Shields), and Thomas Jefferson University (Drs Berd and Mastrangelo), Philadelphia.

Footnotes
Accepted for publication Feb 8, 1985.

Reprint requests to the Research Division, Wills Eye Hospital, Ninth and Walnut streets, Philadelphia, PA 19107 (Dr Donoso).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Optic nerve invasion of uveal melanoma: clinical characteristics and metastatic pattern.
Lindegaard et al.
IOVS 2006;47:3268-3275.
ABSTRACT | FULL TEXT  

Expression and Possible Function of IL-2 and IL-15 Receptors on Human Uveal Melanoma Cells
He et al.
IOVS 2004;45:4240-4246.
ABSTRACT | FULL TEXT  

Screening for Metastasis From Choroidal Melanoma: The Collaborative Ocular Melanoma Study Group Report 23
Diener-West et al.
JCO 2004;22:2438-2444.
ABSTRACT | FULL TEXT  

Uveal Melanoma Expression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptors and Susceptibility to TRAIL-Induced Apoptosis
Ren et al.
IOVS 2004;45:1162-1168.
ABSTRACT | FULL TEXT  

Reduction of Liver Metastasis of Intraocular Melanoma by Interferon-{beta} Gene Transfer
Alizadeh et al.
IOVS 2003;44:3042-3051.
ABSTRACT | FULL TEXT  

Expression of Epidermal Growth Factor Receptor: Risk Factor in Uveal Melanoma
Hurks et al.
IOVS 2000;41:2023-2027.
ABSTRACT | FULL TEXT  

Inhibition of Metastasis of Intraocular Melanomas by Adenovirus-Mediated Gene Transfer of Plasminogen Activator Inhibitor Type 1 (PAI-1) in an Athymic Mouse Model
Ma et al.
Blood 1997;90:2738-2746.
ABSTRACT | FULL TEXT  

Metastatic Uveal Melanoma: Correlation Between Survival Time and Cytomorphometry of Primary Tumors
Donoso et al.
Arch Ophthalmol 1986;104:76-78.
ABSTRACT