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Sheri L. Rowen, MD; Bert M. Glaser, MD

Arch Ophthalmol. 1985;103(5):704-707.

Abstract
• Astrocyte migration was studied using a modified Boyden chamber. Astrocytes migrated in response to a concentration gradient (chemotaxis) of retinal pigment epithelial cell-conditioned medium. In contrast, smooth muscle cell- and corneal fibroblast-conditioned media stimulated random migration (chemokinesis) of astrocytes but not chemotaxis. Furthermore, retinal pigment epithelial cell-conditioned medium stimulates only random migration of smooth muscle cells and corneal fibroblasts. The chemotactic factor produced by retinal pigment epithelial cells appears to have a molecular weight between 10,000 and 30,000 determined by ultrafiltration. Activity is lost after boiling but is stable, with a pH between 2 and 7. These results suggest that in proliferative vitreoretinopathy, retinal pigment epithelial cells on the retina and within the vitreous cavity may release a chemoattractant that stimulates astrocytes to migrate into the vitreous cavity.

Author Affiliations
From the Center for Vitreoretinal Research, Wilmer Ophthalmological Institute, The Johns Hopkins Hospital, Baltimore.

Footnotes
Accepted for publication Dec 20, 1984.

Reprint requests to The Johns Hopkins Hospital, 600 N Wolfe St, Maumenee 119, Baltimore, MD 21205 (Dr Glaser).

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