This Article  • References  • Full text PDF  • Correction  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (268)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Alan B. Scott, MD; Ross A. Kennedy, MD; Harrison A. Stubbs, PhD

Arch Ophthalmol. 1985;103(3):347-350.

Abstract
• Thirty-nine patients with blepharospasm were treated with injections of botulinum A toxin into the lid and brow. The maximum number of injections in one patient was 16 over a period of 24 months. A reduction of abnormal movement occurred in all patients, lasting up to 170 days. Both the amount and the duration of effect were dose dependent. Reinjection for recurrence had effects similar to the original injection. Tearing, dry-eye symptoms, or transient ptosis occurred in 20% of injections, especially in patients who had had previous eyelid surgery.

Author Affiliations
From the Smith-Kettlewell Eye Research Foundation, Medical Research Institute, San Francisco (Drs Scott and Stubbs), and the Department of Ophthalmology, University of British Columbia, Vancouver (Dr Kennedy).

Footnotes
Accepted for publication Jan 16, 1985.

Reprint requests to Smith-Kettlewell Institute of Visual Sciences, 2200 Webster St, San Francisco, CA 94115 (Dr Scott).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The 100 Most Frequently Cited Articles in Ophthalmology Journals
Ohba et al.
Arch Ophthalmol 2007;125:952-960.
ABSTRACT | FULL TEXT  

Botulinum Toxin Treatment of Extraocular Muscles in Rabbits Results in Increased Myofiber Remodeling
Ugalde et al.
IOVS 2005;46:4114-4120.
ABSTRACT | FULL TEXT  

Striatal activation during blepharospasm revealed by fMRI
Schmidt et al.
Neurology 2003;60:1738-1743.
ABSTRACT | FULL TEXT  

Simple and Efficient Method for Heterologous Expression of Clostridial Proteins
Zdanovsky and Zdanovskaia
Appl. Environ. Microbiol. 2000;66:3166-3173.
ABSTRACT | FULL TEXT  

Long-term Enhancement of Botulinum Toxin Injections by Upper-Eyelid Surgery in 14 Patients With Facial Dyskinesias
Mauriello et al.
Arch Otolaryngol Head Neck Surg 1999;125:627-631.
ABSTRACT | FULL TEXT  

An Anatomical Approach to Glabellar Rhytids
Macdonald et al.
Arch Otolaryngol Head Neck Surg 1998;124:1315-1320.
ABSTRACT | FULL TEXT  

Botulinum toxin A treatment of overactive corrugator supercilii in thyroid eye disease
Olver
Br J Ophthalmol 1998;82:528-533.
ABSTRACT | FULL TEXT  

Neuromuscular Blockade in the Management of Cerebral Palsy
Koman et al.
J Child Neurol 1996;11:S23-S28.
ABSTRACT  

10 Years: Over 10 000 Manuscripts
Goldberg
Arch Ophthalmol 1994;112:749-751.
ABSTRACT  

Treatment of Speech and Voice Disorders With Botulinum Toxin
Ludlow
JAMA 1990;264:2671-2675.
ABSTRACT  

Hemifacial Spasm in Infancy
Flueler et al.
Arch Ophthalmol 1990;108:812-815.
ABSTRACT  

Management of Facial Spasm With Clostridium botulinum Toxin, Type A (Oculinum)
Biglan et al.
Arch Otolaryngol Head Neck Surg 1988;114:1407-1412.
ABSTRACT  

Coexistent Meige's Syndrome and Myasthenia Gravis: A Relationship Between Blinking and Extraocular Muscle Fatigue?
Kurlan et al.
Arch Neurol 1987;44:1057-1060.
ABSTRACT  

Experimental Doxorubicin Myopathy: A Permanent Treatment for Eyelid Spasms?
Baker and Wirtschafter
Arch Ophthalmol 1987;105:1265-1268.
ABSTRACT  

Botulinum Toxin Injection of the Vocal Fold for Spasmodic Dysphonia: A Preliminary Report
Miller et al.
Arch Otolaryngol Head Neck Surg 1987;113:603-605.
ABSTRACT  

Treatment of Essential Blepharospasm
POPP
Arch Otolaryngol Head Neck Surg 1986;112:1108-1108.
ABSTRACT  

Blepharospasm With Basal Ganglia Lesions
Jankovic
Arch Neurol 1986;43:866-868.
ABSTRACT  

Botulinum Toxin in the Management of Blepharospasm
Dutton and Buckley
Arch Neurol 1986;43:380-382.
ABSTRACT  

Hemifacial Spasm Treated With Botulinum A Toxin Injection
Savino et al.
Arch Ophthalmol 1985;103:1305-1306.
ABSTRACT