Lipopolysaccharide tolerance inhibits eye inflammation. I. Reduced immune complex or lipopolysaccharide effects
E. L. Howes Jr, M. E. Goldyne, H. D. Perez, I. M. Goldstein and J. T. Rosenbaum
The effect of endotoxin tolerance on ocular inflammation was studied in
rabbits. A single intravenous (IV) injection of endotoxin (bacterial
lipopolysaccharide [LPS]) produced a mild acute iridocyclitis. Repeated
daily (five to seven days) IV injections of LPS (5 micrograms extracted
from Salmonella typhimurium) led to a state of refractoriness or LPS
"tolerance," and ocular inflammation was no longer produced. In contrast to
controls, in rabbits tolerant to LPS, IV LPS failed to elevate
prostaglandin E2, thromboxane B2, or chemotactic factors in the aqueous
humor. Rabbits tolerant to LPS also resisted the increase in vascular
permeability normally induced by an ocular reversed passive Arthus
reaction. These results demonstrated that LPS tolerance can induce
anti-inflammatory effects in the eye.