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I. Reduced Immune Complex or Lipopolysaccharide Effects

Edward L. Howes, Jr, MD; Marc E. Goldyne, MD; H. Daniel Perez, MD; Ira M. Goldstein, MD; James T. Rosenbaum, MD

Arch Ophthalmol. 1985;103(2):257-260.

Abstract
• The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. A single intravenous (IV) injection of endotoxin (bacterial lipopolysaccharide [LPS]) produced a mild acute iridocyclitis. Repeated daily (five to seven days) IV injections of LPS (5 µg extracted from Salmonella typhimurium) led to a state of refractoriness or LPS "tolerance," and ocular inflammation was no longer produced. In contrast to controls, in rabbits tolerant to LPS, IV LPS failed to elevate prostaglandin E₂, thromboxane B₂, or chemotactic factors in the aqueous humor. Rabbits tolerant to LPS also resisted the increase in vascular permeability normally induced by an ocular reversed passive Arthus reaction. These results demonstrated that LPS tolerance can induce anti-inflammatory effects in the eye.

Author Affiliations
From the Departments of Pathology (Dr Howes), Dermatology (Dr Goldyne), and Medicine (Drs Perez and Goldstein), University of California, San Francisco, and the Kuzell Institute for Arthritis Research, Medical Research Institute of San Francisco at Pacific Presbyterian Medical Center (Dr Rosenbaum).

Footnotes
Accepted for publication Aug 28, 1984.

Read in part before the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 6, 1982.

Reprint requests to Kuzell Institute for Arthritis Research, 2200 Webster St, R305, San Francisco, CA 94115 (Dr Rosenbaum).

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