Retinal pigment epithelial cells release an inhibitor of neovascularization
B. M. Glaser, P. A. Campochiaro, J. L. Davis Jr and M. Sato
Human retinal pigment epithelial cells in culture were found to release a
substance (or substances) that causes the regression of new blood vessels
on the chick embryonic yolk sac and inhibits proliferation of fetal bovine
aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts,
under identical test conditions, released detectable inhibitors of
neovascularization or endothelial cell growth. Subconfluent and
superconfluent cultures of human retinal pigment epithelial cells released
higher levels of inhibitor than confluent cultures.
