This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Bert M. Glaser, MD; Peter A. Campochiaro, MD; John L. Davis, Jr; Misao Sato, MD

Arch Ophthalmol. 1985;103(12):1870-1875.

Abstract
• Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts, under identical test conditions, released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human retinal pigment epithelial cells released higher levels of inhibitor than confluent cultures.

Author Affiliations
From the Center for Vitreoretinal Research, Wilmer Ophthalmological Institute, The Johns Hopkins University, Baltimore.

Footnotes
Accepted for publication May 10, 1985.

Reprint requests to The Johns Hopkins Hospital, 600 N Wolfe St, Maumenee 119, Baltimore, MD 21205 (Dr Glaser).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Localization of Collagen XVIII and the Endostatin Portion of Collagen XVIII in Aged Human Control Eyes and Eyes with Age-Related Macular Degeneration
Bhutto et al.
IOVS 2004;45:1544-1552.
ABSTRACT | FULL TEXT  

Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes
Oshima et al.
IOVS 2003;44:1814-1823.
ABSTRACT | FULL TEXT  

Down-regulation of Vascular Endothelial Growth Factor and Up-regulation of Pigment Epithelium-derived Factor. A POSSIBLE MECHANISM FOR THE ANTI-ANGIOGENIC ACTIVITY OF PLASMINOGEN KRINGLE 5
Gao et al.
J. Biol. Chem. 2002;277:9492-9497.
ABSTRACT | FULL TEXT  

Expression and Localization of Angiogenic Inhibitory Factor, Chondromodulin-I, in Adult Rat Eye
Funaki et al.
IOVS 2001;42:1193-1200.
ABSTRACT | FULL TEXT  

Characteristics of Drusen and Bruch's Membrane in Postmortem Eyes With Age-Related Macular Degeneration
Spraul and Grossniklaus
Arch Ophthalmol 1997;115:267-273.
ABSTRACT  

Increased expression of angiogenic growth factors in age-related maculopathy
Kliffen et al.
Br J Ophthalmol 1997;81:154-162.
ABSTRACT | FULL TEXT  

Debridement of the Pig Retinal Pigment Epithelium In Vivo
Del Priore et al.
Arch Ophthalmol 1995;113:939-944.
ABSTRACT  

Vessel Formation by Choroidal Endothelial Cells In Vitro Is Modulated by Retinal Pigment Epithelial Cells
Sakamoto et al.
Arch Ophthalmol 1995;113:512-520.
ABSTRACT  

Granulomatous Reaction to Bruch's Membrane in Age-Related Macular Degeneration
Dastgheib and Green
Arch Ophthalmol 1994;112:813-818.
ABSTRACT  

Systemic Amiloride Inhibits Experimentally Induced Neovascularization
Avery et al.
Arch Ophthalmol 1990;108:1474-1476.
ABSTRACT  

Bovine Retinal Pigment Epithelium Promotes Proliferation of Choroidal Endothelium In Vitro
Morse et al.
Arch Ophthalmol 1989;107:1659-1663.
ABSTRACT  

Response of Pig Retinal Pigment Epithelium to Laser Photocoagulation in Organ Culture
Del Priore et al.
Arch Ophthalmol 1989;107:119-122.
ABSTRACT  

Retinal Pigment Epithelial Cells in Culture Produce Retinal Vascular Mitogens
Wong et al.
Arch Ophthalmol 1988;106:1439-1443.
ABSTRACT  

Morphology of Pig Retinal Pigment Epithelium Maintained in Organ Culture
Del Priore et al.
Arch Ophthalmol 1988;106:1286-1290.
ABSTRACT  

Extracellular Modulating Factors and the Control of Intraocular Neovascularization: An Overview
Glaser
Arch Ophthalmol 1988;106:603-607.
ABSTRACT  

Hemorrhagic Peripheral Pigment Epithelial Disease
Delaney et al.
Arch Ophthalmol 1988;106:646-650.
ABSTRACT  

Macular Grid Photocoagulation: An Experimental Study on the Primate Retina
Wilson et al.
Arch Ophthalmol 1988;106:100-105.
ABSTRACT  

Clinical Characteristics of Choroidal Neovascular Membranes
Bressler et al.
Arch Ophthalmol 1987;105:209-213.
ABSTRACT  

Calcification of Bruch's Membrane in Angioid Streaks With Homozygous Sickle Cell Disease
Jampol et al.
Arch Ophthalmol 1987;105:93-98.
ABSTRACT  

Ultrastructure of Bruch's Membrane After Krypton Laser Photocoagulation: II. Repair of Bruch's Membrane and the Role of Macrophages
Pollack et al.
Arch Ophthalmol 1986;104:1377-1382.
ABSTRACT  

Retinal Pigment Epithelium and Endothelium
Korte
Arch Ophthalmol 1986;104:802-804.
ABSTRACT  

A New Look at the Retinal Pigment Epithelium and Its Neighbors
Patz
Arch Ophthalmol 1985;103:1794-1795.
ABSTRACT  

Endothelial Cells Release a Chemoattractant for Retinal Pigment Epithelial Cells In Vitro
Campochiaro and Glaser
Arch Ophthalmol 1985;103:1876-1880.
ABSTRACT