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Effects on Experimental Choroidal Melanoma

Klaus G. Riedel, MD; Paul P. Svitra, MD; Johanna M. Seddon, MD; Daniel M. Albert, MD; Evangelos S. Gragoudas, MD; Andreas M. Koehler, MA; D. Jackson Coleman, MD; Joan Torpey, MD; Frederic L. Lizzi, EngScD; Jack Driller, MS

Arch Ophthalmol. 1985;103(12):1862-1869.

Abstract
• Ultrasonically induced hyperthermia (4.75 MHz) and proton irradiation (160 meV) were evaluated alone and combined to treat experimental choroidal melanoma in 58 rabbit eyes. Threshold tumoricidal doses were established for each modality. Therapy was performed combining subthreshold doses of heat and radiation. Focused ultrasonic energy via an external beam was found to deliver well-localized heat to an intraocular tumor. Ectopic temperature elevations due to soft-tissuebone interfaces were alleviated by modifying beam alignment. The results indicate that hyperthermia (43 °C for one hour) potentiated the tumoricidal effects of radiation, while sparing normal ocular structures. Therefore, we believe that experimental hyperthermia is suitable as an adjuvant treatment modality. This shows that ultrasound hyperthermia has the potential to increase the efficacy of proton irradiation by lowering radiation doses and thus decreasing posttreatment ocular morbidity in human intraocular malignancies.

Author Affiliations
From the David G. Cogan Eye Pathology Laboratory (Drs Riedel, Svitra, and Albert) and the Retina Service (Drs Seddon and Gragoudas), Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston; Harvard Cyclotron Laboratory, Cambridge, Mass (Mr Koehler); the Department of Ophthalmology, Cornell University Medical College, New York (Drs Svitra, Coleman, and Torpey); and the Riverside Research Institute, New York (Dr Lizzi and Mr Driller).

Footnotes
Accepted for publication Aug 12, 1985.

Reprint requests to the David G. Cogan Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (Dr Albert).

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