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Shigeto Hirose, MD; Shigeaki Ohno, MD; Hidehiko Matsuda, MD

Arch Ophthalmol. 1985;103(12):1837-1839.

Abstract
• Twenty-two Japanese patients with glaucomatocyclitic crisis were typed for HLA-A, HLA-B, and HLA-C antigens to detect the immunogenetic factors in this disease. It was shown that HLA-Bw54 was present in nine (41%) of 22 patients, a significant increase even after correcting the P value for the number of antigens studied. The haplotype frequency of HLA-Bw54-Cw1 showed a significant association, and it was not due to linkage disequilibrium in the Japanese. Our results suggest that immunogenetic factors closely associated with the major histocompatibility complex may play an important role in the pathogenesis of glaucomatocyclitic crisis.

Author Affiliations
From the Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan.

Footnotes
Accepted for publication July 8, 1985.

Reprint requests to Department of Ophthalmology, Hokkaido University School of Medicine, N-15, W-7, Kitaku, Sapporo, Hokkaido 060, Japan (Dr Ohno).

This study was supported in part by grants 59570745 and 60570825 from the Ministry of Education, Science and Culture, Tokyo.

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