The effects of subconjunctival miconazole in the treatment of experimental Candida keratitis in rabbits

Y. Ishibashi and H. E. Kaufman

Subconjunctival miconazole (1.2 mg/day for three weeks) produced a marked clinical improvement in the ocular lesions produced by inoculation with Candida albicans in a group of ten rabbits. Clinical scores of affected eyes were significantly lower in this treated group than in a control group of ten untreated rabbits. All cultures of corneal scrapings were negative on the 15th day after inoculation in the treated group, while three cultures were still positive at the end of the experiment (day 21) in the control group. Histopathologic examination showed considerably less-severe inflammatory changes in the eyes of treated animals compared with those of control animals.