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David T. Tse, MD; Robert Folberg, MD; Kenneth Moore, PhD

Arch Ophthalmol. 1985;103(10):1515-1517.

Abstract
• An eyelid with freshly applied black eyeliner pigment was examined histologically. X-ray microanalysis of the pigment suspension from the manufacturer's vial indicated that its composition was 98% iron and 2% titanium. Transmission electron microscopic examination disclosed that particles were in the extracellular matrix; intracellular particles were not seen. By light microscopy, implant material was detected in various levels of the dermis and was found in dermal lymphatics as well as within and surrounding a hair follicle. Our study suggests that systemic exposure to the implant material is possible and offers explanations for permanent eyelash loss, which we have seen following this procedure.

Author Affiliations
From the Department of Ophthalmology, University of Iowa Hospitals and Clinics (Drs Tse and Folberg), and the Central Electron Microscopy Facility, University of Iowa (Dr Moore), Iowa City.

Footnotes
Accepted for publication Aug 14, 1985.

Reprint requests to the Division of Oculoplastic, Orbital, and Oncology Services, Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242 (Dr Tse).

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ABSTRACT