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A New Cephalosporin With Aqueous Humor Levels Effective Against Enterobacteriaceae

Judith L. Axelrod, MD; James C. Newton, MD; Chalermpong Sarakhun, MD; Richard D. Lester, MD; Kenneth Merhige, MD; Rochelle L. Peck, MD; Thomas J. Francomano, MD; Mohammed Z. Sheikh

Arch Ophthalmol. 1985;103(1):71-72.

Abstract
• One- or two-gram doses of ceftriaxone were administered intravenously to 30 patients before cataract extraction. With the 1-g dose, mean aqueous humor concentrations of 0.93 and 0.88 µg/mL were found at approximately 2 and 12 hours after administration, respectively. With the 2-g dose, a mean level of 2.47 µg/mL was observed at two hours; levels of more than 2 µg/mL were found in two patients 13 hours after administration. Both the 1- and 2-g doses thus produce aqueous humor levels many times higher than the minimum inhibitory concentration of ceftriaxone for 90% of most Enterobacteriaceae, excluding Pseudomonas. Concentrations adequate for Staphylococcus aureus and Staphylococcus epidermidis were not, however, obtained.

Author Affiliations
From the Departments of Medicine (Dr Axelrod and Mr Sheikh) and Ophthalmology (Drs Newton, Sarakhun, Lester, Merhige, Peck, and Francomano), St Luke's-Roosevelt Hospital Center, New York City.

Footnotes
Accepted for publication Aug 23, 1984.

Reprint requests to Division of Infectious Diseases and Epidemiology, Department of Medicine, St Luke's-Roosevelt Hospital Center, 421 W 113th St, New York, NY 10025 (Dr Axelrod).

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