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  Vol. 103 No. 1, January 1985 TABLE OF CONTENTS
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Ceftriaxone. A new cephalosporin with aqueous humor levels effective against enterobacteriaceae

J. L. Axelrod, J. C. Newton, C. Sarakhun, R. D. Lester, K. Merhige, R. L. Peck, T. J. Francomano and M. Z. Sheikh

One- or two-gram doses of ceftriaxone were administered intravenously to 30 patients before cataract extraction. With the 1-g dose, mean aqueous humor concentrations of 0.93 and 0.88 microgram/mL were found at approximately 2 and 12 hours after administration, respectively. With the 2-g dose, a mean level of 2.47 micrograms/mL was observed at two hours; levels of more than 2 micrograms/mL were found in two patients 13 hours after administration. Both the 1- and 2-g doses thus produce aqueous humor levels many times higher than the minimum inhibitory concentration of ceftriaxone for 90% of most Enterobacteriaceae, excluding Pseudomonas. Concentrations adequate for Staphylococcus aureus and Staphylococcus epidermidis were not, however, obtained.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Ocular Manifestations of Whipple Disease: An Atypical Presentation
Williams et al.
Arch Ophthalmol 1998;116:1232-1234.
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