Ceftriaxone. A new cephalosporin with aqueous humor levels effective against enterobacteriaceae
J. L. Axelrod, J. C. Newton, C. Sarakhun, R. D. Lester, K. Merhige, R. L. Peck, T. J. Francomano and M. Z. Sheikh
One- or two-gram doses of ceftriaxone were administered intravenously to 30
patients before cataract extraction. With the 1-g dose, mean aqueous humor
concentrations of 0.93 and 0.88 microgram/mL were found at approximately 2
and 12 hours after administration, respectively. With the 2-g dose, a mean
level of 2.47 micrograms/mL was observed at two hours; levels of more than
2 micrograms/mL were found in two patients 13 hours after administration.
Both the 1- and 2-g doses thus produce aqueous humor levels many times
higher than the minimum inhibitory concentration of ceftriaxone for 90% of
most Enterobacteriaceae, excluding Pseudomonas. Concentrations adequate for
Staphylococcus aureus and Staphylococcus epidermidis were not, however,
obtained.
