This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Nina L. Zasorin, MD; Robert D. Yee, MD; Robert W. Baloh, MD

Arch Ophthalmol. 1985;103(1):55-58.

Abstract
• Ophthalmoplegia, ataxia, and areflexia are present in a distinctive syndrome called Fisher's syndrome. Eye-movement recordings were used to analyze ophthalmoplegia and other eye-movement abnormalities in three patients. Disorders of supranuclear ocular motor pathways (palsy of upward gaze and internuclear ophthalmoplegia) and peripheral cranial nerve palsies could account for the ophthalmoplegia. In one patient, computed tomography demonstrated a lucency in the midbrain that could be correlated with palsy of upward gaze and bilateral internuclear ophthalmoplegia. Eye-movement abnormalities characteristic of lesions of the midline structures of the cerebellum were documented in two patients. A review of reported cases of Fisher's syndrome and brain-stem encephalitis suggested that these syndromes comprise a spectrum of a reversible, parainfectious process affecting the peripheral cranial nerves and CNS.

Author Affiliations
From the Department of Neurology and Reed Neurological Research Center (Drs Zasorin and Baloh) and the Department of Ophthalmology and the Jules Stein Eye Institute (Dr Yee), University of California-Los Angeles.

Footnotes
Accepted for publication June 7, 1984.

Reprint requests to the Jules Stein Eye Institute, 800 Westwood Plaza, Los Angeles, CA 90024 (Dr Yee).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?