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Angiotensin-Converting Enzyme Activity in Human Aqueous Humor
Robert N. Weinreb, MD;
Robert Sandman, PhD;
Mark I. Ryder, DMD;
Thomas R. Friberg, MD
Arch Ophthalmol. 1985;103(1):34-36.
Abstract
• We measured aqueous angiotensin-converting enzyme (ACE) activity in 37 patients. Patients with granulomatous uveitis and probable sarcoidosis (based on increased serum ACE activity or characteristic radiologic findings) had a significant increase in aqueous ACE activity compared with normal subjects. Aqueous ACE activity was also significantly elevated in patients with sarcoid who had normal serum ACE activity. We believe that measurement of aqueous ACE activity should be considered in patients with uveitis who have normal serum ACE activity and are suspected of having sarcoidosis.
Author Affiliations
From the Departments of Ophthalmology, University of California, San Diego (Dr Weinreb) and San Francisco (Dr Sandman), the University of Texas Health Science Center, Dallas (Dr Friberg), and the Department of Oral Biology, University of California, San Francisco (Dr Ryder).
Footnotes
Accepted for publication June 26, 1984.
Reprint requests to the Department of Ophthalmology, UCSD Medical Center, 225 Dickinson St (H-898), San Diego, CA 92103 (Dr Weinreb).
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