Angiotensin-converting enzyme activity in human aqueous humor
R. N. Weinreb, R. Sandman, M. I. Ryder and T. R. Friberg
We measured aqueous angiotensin-converting enzyme (ACE) activity in 37
patients. Patients with granulomatous uveitis and probable sarcoidosis
(based on increased serum ACE activity or characteristic radiologic
findings) had a significant increase in aqueous ACE activity compared with
normal subjects. Aqueous ACE activity was also significantly elevated in
patients with sarcoid who had normal serum ACE activity. We believe that
measurement of aqueous ACE activity should be considered in patients with
uveitis who have normal serum ACE activity and are suspected of having
sarcoidosis.
