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Actin Filaments in Contracting Preretinal Membranes
Ingolf H. L. Wallow, MD;
Thomas S. Stevens, MD;
Marion L. Greaser, PhD;
Colleen Bindley;
Robin Wilson
Arch Ophthalmol. 1984;102(9):1370-1375.
Abstract
• In 14 patients, preretinal membranes, causing retinal traction and severe visual impairment, were removed by vitrectomy and evaluated by light and electron microscopy using myosin subfragment-1 to stain actin filaments. Eight membranes were of vascular origin, six of nonvascular origin. All but one contained bundles of oriented actin filaments within a number of their nonvascular stroma cells, suggesting that the contractile protein action may have been involved in their clinically observed contraction.
Author Affiliations
From the Department of Ophthalmology, University of Wisconsin Medical School (Drs Wallow and Stevens and Mss Bindley and Wilson), and the Muscle Biology Laboratory, University of Wisconsin-Madison (Dr Greaser).
Footnotes
Accepted for publication Jan 25, 1984.
Presented in part as a poster presentation at the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 1-6, 1983; abstracted in Investigative Ophthalmology and Visual Science 1983; 24(suppl):290.
Reprint requests to the Department of Ophthalmology, University of Wisconsin Medical School, 600 Highland Ave, Madison, WI 53792 (Dr Wallow).
This study was supported in part by Public Health Service research grants EY01634 and EY03630, Research Career Development Award 00135 (Dr Wallow), and grant HL18612 and by the College of Agricultural and Life Science, University of Wisconsin-Madison (Dr Greaser).
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