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Correlation of OCTOPUS Perimetry With Fluorescein Angiography

James A. Bell, PhD; Steven E. Feldon, MD

Arch Ophthalmol. 1984;102(9):1294-1298.

Abstract
• The capillary perfusion of 14 eyes with nonproliferative diabetic retinopathy and 14 eyes with retinal branch vein occlusion was assessed by wide-angle fluorescein angiography. Regional perfusion was directly correlated with visual sensitivity determined by OCTOPUS-automated static perimetry. Visual function was found to correlate linearly with capillary perfusion in both diseases. Occasional foci of decreased visual sensitivity that corresponded to a region of good capillary perfusion were found in the central fields of diabetics. Although capillary dropout appears to be the major cause of decreased visual sensitivity in microangiopathy, local metabolic factors may also play a role. Further studies are required to determine whether foci of decreased function are predictive of future capillary dropout or neovascularization.

Author Affiliations
From the Departments of Ophthalmology and Neurological Surgery, University of Southern California, Los Angeles, and the Estelle Doheny Eye Foundation, Los Angeles.

Footnotes
Accepted for publication Feb 13, 1984.

Reprint requests to Estelle Doheny Eye Foundation Building, 1355 San Pablo St, Los Angeles, CA 90033 (Dr Feldon).

This study was supported in part by Research to Prevent Blindess Inc, New York City.

Some of the patients were referred by Kenneth R. Diddie, MD. John Weiner, DrPH, provided statistical consultation. Carol Miedema and Ann Dawson assisted in preparation of the manuscript.

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