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III. Fluorescein Angiographic Studies

Eeva Nikoskelainen, MD; William F. Hoyt, MD; Kari Nummelin; Howard Schatz, MD

Arch Ophthalmol. 1984;102(7):981-989.

Abstract
• Fluorescein angiography was performed in nine members of families with Leber's disease. Serial studies were obtained in four men observed from asymptomatic to atrophic stages. Peripapillary microangiopathy was observed in six of nine asymptomatic eyes. Arteriovenous shunting occurred in the telangiectatic vascular bed. These changes remained stable in some eyes and progressed in others. In the acute stage, arteries and telangiectatic vessels were maximally dilated and flow was rapid. Angiography showed florid shunting in lower and upper vascular arcades and reduced filling of papillomacular capillaries. Vessels of the shunting vascular bed gradually narrowed irregularly. In the atrophic stage, disc vascularity diminished and arteriovenous circulation time increased markedly. Arterioles narrowed and peripapillary microangiopathy disappeared. These findings support our contention that Leber's disease is a hereditary vascular neuroretinopathy.

Author Affiliations
From the Department of Ophthalmology, University of Turku (Finland) (Dr Nikoskelainen and Mr Nummelin); the Neuro-ophthalmology Unit (Dr Hoyt) and the Department of Ophthalmology (Dr Schatz), University of California San; Francisco.

Footnotes
Accepted for publication Oct 3, 1983.

Reprint requests to Department of Ophthalmology, University of Turku (TYKS), Kiinamyllynkatu 4-8, SF-20520 Turku 52, Finland (Dr Nikoskelainen).

This study was supported by grants from the Paulo Foundation, Helsinki, and from the Academy of Finland.

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