This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (15)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Andrew K. Vine, MD; Anne M. Kisly; A. Lorris Betz, MD, PhD; William F. Howatt, MD

Arch Ophthalmol. 1984;102(7):1083-1085.

Abstract
• Vitreous fluorophotometry (VF) has been used to study the blood-retinal barrier in rats with streptozocin-induced diabetes. Subsequent investigations have shown that many variables other than diabetes influence VF values. With the use of a commercially available fluorophotometer, we assessed VF measurements in diabetic rats while simultaneously measuring other variables, including plasma fluorescein level, free plasma fluorescein level, and blood pH. Mean total plasma fluorescein concentration, mean free plasma fluorescein concentration, and mean midvitreous fluorescein concentration were significantly decreased in diabetic animals. The mean ratio of midvitreous fluorescein concentration to total plasma fluorescein concentration was significantly increased in diabetic animals. In comparison with nondiabetic animals, the diabetic animals showed no significant difference in blood pH or mean ratio of free plasma fluorescein concentration to total plasma fluorescein concentration. Our findings confirm an early derangement of the blood-retinal barrier in diabetic rats.

Author Affiliations
From the Ocular Fluorophotometry Research Unit, Department of Ophthalmology (Dr Vine and Ms Kisly), and the Department of Pediatrics and Communicable Diseases (Drs Betz and Howatt), The University of Michigan, Ann Arbor.

Footnotes
Accepted for publication Dec 23, 1983.

Reprint requests to Vitreo-Retina Service, The W. K. Kellogg Eye Center, The University of Michigan, 1000 Wall St, Ann Arbor, MI 48105 (Dr Vine).

This study was supported by grant AM-20572-06 from the National Institutes of Health, and by the Knights Templar Eye Foundation, Inc.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Free Plasma Fluorescein
Kisly and Vine
Arch Ophthalmol 1985;103:1457-1457.
ABSTRACT