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George A. Williams, MD; Diane L. Hatchell, PhD; B. David Collier, MD; Janet Knobel

Arch Ophthalmol. 1984;102(6):930-931.

Abstract
• Erythrocytes from diabetic patients manifest decreased deformability and increased adherence. These abnormal membrane properties may diminish the ability of erythrocytes (RBCs) from diabetics to undergo deformation in passage through the trabecular meshwork. Using sodium chromate Cr 51-labeled RBCs from type I diabetic patients with proliferative retinopathy and normal control subjects, we studied RBC clearance from the rabbit anterior chamber. The mean time for 50% clearance (T₅₀) of RBCs from diabetics (76 hours) was significantly longer than that for RBCs from normal subjects (19.5 hours). In this model, RBCs from diabetics have a slower clearance from the anterior chamber than do RBCs from normal subjects.

Author Affiliations
From the Departments of Ophthalmology (Drs Williams and Hatchell), Physiology (Dr Hatchell), and Nuclear Medicine (Dr Collier and Ms Knobel), Medical College of Wisconsin, Milwaukee, and the Research Service, Wood Veterans Administration Medical Center, Milwaukee (Dr Hatchell).

Footnotes
Accepted for publication Oct 21, 1983.

Reprint requests to the Department of Ophthalmology, Medical College of Wisconsin, 8700 W Wisconsin Ave, Milwaukee, WI 53226 (Dr Williams).

This investigation was supported in part by research grant EY01436 and Ophthalmic Research Center grant EY01931 from the National Eye Institute, Bethesda, Md; by an unrestricted grant from Research to Prevent Blindness, Inc, New York; and by Veterans Administration medical research funds.

Dr Hatchell is a Research to Prevent Blindness, Inc, William and Mary Greve International Research Scholar.

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