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Treatment of Xerophthalmia With Retinol, Tretinoin, and Etretinate
Diane L. Hatchell, PhD;
Mary Faculjak;
Diana Kubicek
Arch Ophthalmol. 1984;102(6):926-927.
Abstract
• Topical retinol, tretinoin (all-transretinoic acid) and etretinate (a synthetic retinoid) were used in rabbits to treat experimental xerophthalmia due to vitamin A deficiency. Both 0.2% retinol and 0.1% and 0.2% tretinoin effectively reversed abnormal corneal epithelial keratinization within one to two days and restored corneal clarity within two to four days following topical application three times per day. Etretinate was ineffective in the concentration used (0.2%). In addition, application of tretinoin to one eye effectively reversed xerophthalmic changes in the other eye. Retinol did not have an effect on the other eye.
Author Affiliations
From the Departments of Ophthalmology (Dr Hatchell and Mesdames Faculjak and Kubicek) and Physiology (Dr Hatchell), Medical College of Wisconsin, and the Research Service, Wood Veterans Administration Medical Center (Dr Hatchell), Milwaukee. Dr Hatchell is a Research to Prevent Blindness Inc, William and Mary Greve International Research Scholar and is now at the Duke University Eye Center, and the Durham Veterans Administration Medical Center, Durham, NC.
Footnotes
Accepted for publication Aug 29, 1983.
Reprint requests to Duke University Eye Center, Box 3802, Durham, NC 27710 (Dr Hatchell).
This study was supported in part by research grant EY01436 and Ophthalmic Research Center grant EY01931 from the National Eye Institute, by an unrestricted grant from Research to Prevent Blindness, Inc, New York City, and by VA Medical Research funds.
Etretinate was provided by Hoffmann-La Roche, Inc.
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