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Ceftazidime Concentrations in Human Aqueous Humor
Judith L. Axelrod, MD;
Richard S. Kochman, MD;
Marc A. Horowitz, MD;
Lynda Youngworth, MD
Arch Ophthalmol. 1984;102(6):923-925.
Abstract
• Two grams of ceftazidime was given to 25 patients before cataract surgery. Mean aqueous humor concentrations of 2.8, 3.2, 3.39, and 1.94 µg/mL were observed 30 minutes and 1, 2, 4, and 6 hours, respectively, after administration of the drug. These concentrations are many times higher than the minimum inhibitory concentration (MIC) of ceftazidime against 90% (MIC90) of isolates of Escherichia coli, Klebsiella sp, Proteus mirabilis, and indole-positive Proteus sp. The peak aqueous humor level was also equivalent to or slightly higher than the MIC90 for Pseudomonas aeruginosa.
Author Affiliations
From the Departments of Medicine (Dr Axelrod) and Ophthalmology (Drs Kochman, Horowitz, and Youngworth), St Luke's-Roosevelt Hospital Center, New York.
Footnotes
Accepted for publication July 25, 1983.
Read at the 22nd Interseience Conference on Antimicrobial Agents and Chemotherapy, Miami Beach, Oct 6, 1982.
Reprint requests to Division of Infectious Diseases and Epidemiology, Department of Medicine, St Luke's-Roosevelt Hospital Center, Amsterdam Avenue at 114th Street, New York, NY 10025 (Dr Axelrod).
This study was supported by a grant from Glaxo Inc, Research Triangle Park, NC.
Mohammed Sheikh provided technical assistance.
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ABSTRACT
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