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Akitoshi Yoshida, MD; Hideki Furukawa, MD; Francois C. Delori, PhD; Sven-Erik Bursell, PhD; Clement L. Trempe, MD; J. Wallace McMeel, MD

Arch Ophthalmol. 1984;102(6):857-860.

Abstract
• Twenty eyes of 17 normal subjects with or without posterior vitreous detachment (PVD) were examined to investigate the influence of various types of PVD on vitreous fluorophotometric readings. Biomicroscopic examinations of the vitreous body were performed with an El Bayadi-Kajiura preset lens, and the findings were classified according to the extent of vitreous detachment and the position of the posterior hyaloid membrane when the eye was stationary. Equivalent fluorescein concentration profiles along various directions in the vitreous cavity were obtained with vitreous fluorophotometry. The degree of PVD significantly affected the measurements. Close to the retina, fluorescein concentrations were significantly higher when the subhyaloid space was sampled than when the vitreous gel was sampled. Our findings have implications for vitreous fluorophotometric assessment of the permeability of the blood-retinal barrier.

Author Affiliations
From the Eye Research Institute of Retina Foundation (Drs Yoshida, Furukawa, Delori, Bursell, Trempe, and McMeel), and the Retina Associates (Drs Trempe and McMeel), Boston. Dr Bursell is now with the Joslin Diabetes Center, Boston.

Footnotes
Accepted for publication Aug 29, 1983.

Reprint requests to Library, Eye Research Institute, 20 Staniford St, Boston, MA 02114.

This work was supported in part by grant R01-EY02164 from the National Eye Institute.

Gail D. Collas, Gilbert T. Feke, PhD, Douglas G. Goger, and Alex E. Jalkh, MD, provided suggestions.

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