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Neovascular Glaucoma After Photoradiation Therapy for Uveal Melanoma
Richard A. Lewis, MD;
David T. Tse, MD;
Charles D. Phelps, MD;
Thomas A. Weingeist, PhD, MD
Arch Ophthalmol. 1984;102(6):839-842.
Abstract
• We describe two patients (two eyes) with neovascular glaucoma following photoradiation therapy (PRT) for ciliary body and iris melanoma. Histopathologic examination in one eye eight months after treatment disclosed widespread tumor necrosis. The second patient with iris melanoma showed total clinical disappearance of the lesion and regression of iris neovascularization six months later. The cause of the neovascular glaucoma is uncertain. The marked tumor necrosis induced by PRT might have resulted in release of a vasoproliferative factor that, in turn, led to the development of rubeosis and neovascular glaucoma.
Author Affiliations
From the Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City. Dr Lewis was a fellow of the Heed Foundation; he is now with the University of California-Davis.
Footnotes
Accepted for publication Dec 5, 1983.
Reprint requests to the Department of Ophthalmology, University of Iowa Hospitals, Iowa City, IA 52242 (Dr Tse).
This investigation was funded in part by support grant RR 05372 from the Biomedical Research Support Branch, Division of Research Facilities and Resources, National Institutes of Health (Dr Tse) and by grant IN-122C from the American Cancer Society (Dr Tse).
Vernon Hermsen, MD, and Karl Ossoinig, MD, performed the ultrasound evaluations and interpretations.
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