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David T. Tse, MD; Jonathan J. Dutton, MD, PhD; Thomas A. Weingeist, MD, PhD; Vernon M. Hermsen, MD; Robert C. Kersten, MD

Arch Ophthalmol. 1984;102(6):833-838.

Abstract
• Photoradiation therapy (PRT) is a new technique that is currently under investigation for the treatment of a variety of solid malignant tumors. The technique involves systemic administration of hematoporphyrin derivative (HpD), a photosensitizing compound that is preferentially retained by malignant cells and photoactivation of the neoplasm with red light (630 nm) to achieve selective destruction of cancer cells. We used HpD PRT for seven patients with malignant melanoma of the uvea and conclude that initial results of HpD PRT for uveal malignant melanoma are encouraging and justify further investigation.

Author Affiliations
From the Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City. Dr Dutton was a Heed Ophthalmic fellow, 1982-1983. He is now with the Department of Ophthalmology, Duke University Eye Center, Durham, NC.

Footnotes
Accepted for publication Nov 25, 1983.

Reprint requests to Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242 (Dr Tse).

This investigation was supported in part by Biomedical Research support grant RR05372 from the Biomedical Research Support Branch, Division of Research Facilities and Resources, National Institutes of Health (Dr Tse) and aided by grant IN-122 C from the American Cancer Society (Dr Tse).

Jane Duwa typed this manuscript. William Stwalley, PhD, Paul Kleiber, PhD, and John Bahns, PhD, from the Iowa Laser Facility provided technical assistance. Nancy Ridenour and Jean Prybil also assisted in patient care.

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