 |
|
Experimental Ocular Herpetic Infections in RabbitsTreatment With 9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine
Kendall O. Smith, PhD;
Sherie L. Hodges;
Wiebke L. Kennell;
Karen S. Galloway;
Robert H. Poirier, MD;
Kelvin K. Ogilvie, PhD;
Ukken O. Cheriyan, MS
Arch Ophthalmol. 1984;102(5):778-781.
Abstract
• A new acyclic nucleoside, 9-([2hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BIOLF-62), was found to be efficacious in the treatment of experimental ocular herpes simplex virus infections in rabbits. Complete healing of herpetic lesions occurred in a majority of animals after six days of topical treatment, three times per day. No toxic effects were observed in uninfected, drug-treated eyes. The BIOLF-62 treatment blocked viral replication in infected eyes sufficiently to make recovery of virus from any of the drug-treated eyes impossible, whereas virus was recovered from all placebo-treated eyes.
Author Affiliations
From the Departments of Microbiology (Dr Smith, Mss Hodges and Galloway, and Mr Kennell) and Ophthalmology (Dr Poirier), The University of Texas Health Science Center at San Antonio; and the Department of Chemistry, McGill University, Montreal (Dr Ogilvie and Mr Cheriyan).
Footnotes
Accepted for publication May 23, 1983.
Read in part at the 82nd annual meeting of the American Society of Microbiology, Atlanta, March 9, 1982.
Reprint requests to Department of Microbiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78284 (Dr Smith).
This study was supported by a grant from Bio Logicals, Toronto, Canada.
The type 1 herpes simplex virus, Patton strain, was provided by Fred Rapp, PhD, Pennsylvania State University College of Medicine, Hershey.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
|
