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Kim S. Mallick, MD; Ran C. Zeimer, PhD; Gerald A. Fishman, MD; Norman P. Blair, MD; Robert J. Anderson, PhD

Arch Ophthalmol. 1984;102(5):691-696.

Abstract
• The function of the blood-retinal barrier was assessed by vitreous fluorophotometry in 12 patients with various genetic types of retinitis pigmentosa and in 11 normal subjects. The measurements were corrected to minimize the effect of artifacts. We evaluated the inward penetration of fluorescein sodium across the blood-retinal barrier and determined the outward permeability coefficient for fluorescein by interpreting the data with a pharmacokinetic computer model. Patients with retinitis pigmentosa had increased inward permeability and decreased outward permeability to fluorescein in comparison with values of normal subjects.

Author Affiliations
From the Ophthalmology Department, Eye and Ear Infirmary (Drs Mallick, Zeimer, Fishman, and Blair), and the Epidemiology-Biometry Program, School of Public Health (Dr Anderson), University of Illinois, Chicago.

Footnotes
Accepted for publication Sept 26, 1983.

Reprint requests to Eye and Ear Infirmary, University of Illinois, 1855 W Taylor St, Chicago, IL 60612 (Dr Fishman).

This investigation was supported in part by core grant 1P30EY01792 and grants EY3453, EY3841, EY703802, and EY3106 from the National Eye Institute; Bethesda, Md; by an unrestricted grant and Manpower Award from Research to Prevent Blindness, Inc, New York; and by a research grant from the National Retinitis Pigmentosa Foundation, Baltimore.

Morton Goldberg, MD, and Maxine Gere reviewed the manuscript. Terry Kevil assisted in typing the manuscript. Tom Young provided photographic assistance. Linda Warren assisted in preparing the illustrations. Mark Rusin, MS, provided technical assistance in vitreous fluorophotometry.

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