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  Vol. 102 No. 5, May 1984 TABLE OF CONTENTS
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Multiple Evanescent White Dot Syndrome

II. Electrophysiology of the Photoreceptors During Retinal Pigment Epithelial Disease

Paul A. Sieving, MD, PhD; Gerald A. Fishman, MD; Lee M. Jampol, MD; David Pugh, MD

Arch Ophthalmol. 1984;102(5):675-679.


Abstract

• We performed electrophysiologic studies of photoreceptor function in three patients with multiple evanescent white dot syndrome. During the acute stage, while the visual acuity was impaired, the electroretinogram (ERG) a-wave and the early receptor potential (ERP) amplitudes were profoundly decreased. The ERP regeneration times, determined for one subject, were prolonged. These findings suggest that photoreceptor function was impaired (abnormal a-wave), the effective visual pigment optical density of the outer segments was markedly reduced (ERP amplitude), and visual pigment regeneration was abnormal (ERP regeneration kinetics). During the recovery stage, the ERG and ERP amplitudes and visual acuity returned to normal. Our patients' disease seemed to be primarily of the retinal pigment epithelium (RPE). The decreased visual pigment density and prolonged regeneration kinetics emphasize the physiologic dependence of the sensory retina on the RPE.



Author Affiliations

From the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago. Dr Jampol is currently with the Department of Ophthalmology, Northwestern University, Chicago.


Footnotes

Accepted for publication Nov 30, 1983.

Reprint requests to Berman-Gund Laboratory, 243 Charles St, Boston, MA 02114 (Dr Sieving).

This work was supported by grants from Fight For Sight, New York (Dr Sieving) and the National Retinitis Pigmentosa Foundation, Baltimore (Dr Fishman), and by core grant EY1792 and training grant EY7038 from the National Eye Institute to the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago.

Morton F. Goldberg, MD, and Joel Pokorny, PhD, commented on the manuscript, and Maxine Gere edited it.



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