This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (47)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

II. Electrophysiology of the Photoreceptors During Retinal Pigment Epithelial Disease

Paul A. Sieving, MD, PhD; Gerald A. Fishman, MD; Lee M. Jampol, MD; David Pugh, MD

Arch Ophthalmol. 1984;102(5):675-679.

Abstract
• We performed electrophysiologic studies of photoreceptor function in three patients with multiple evanescent white dot syndrome. During the acute stage, while the visual acuity was impaired, the electroretinogram (ERG) a-wave and the early receptor potential (ERP) amplitudes were profoundly decreased. The ERP regeneration times, determined for one subject, were prolonged. These findings suggest that photoreceptor function was impaired (abnormal a-wave), the effective visual pigment optical density of the outer segments was markedly reduced (ERP amplitude), and visual pigment regeneration was abnormal (ERP regeneration kinetics). During the recovery stage, the ERG and ERP amplitudes and visual acuity returned to normal. Our patients' disease seemed to be primarily of the retinal pigment epithelium (RPE). The decreased visual pigment density and prolonged regeneration kinetics emphasize the physiologic dependence of the sensory retina on the RPE.

Author Affiliations
From the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago. Dr Jampol is currently with the Department of Ophthalmology, Northwestern University, Chicago.

Footnotes
Accepted for publication Nov 30, 1983.

Reprint requests to Berman-Gund Laboratory, 243 Charles St, Boston, MA 02114 (Dr Sieving).

This work was supported by grants from Fight For Sight, New York (Dr Sieving) and the National Retinitis Pigmentosa Foundation, Baltimore (Dr Fishman), and by core grant EY1792 and training grant EY7038 from the National Eye Institute to the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago.

Morton F. Goldberg, MD, and Joel Pokorny, PhD, commented on the manuscript, and Maxine Gere edited it.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Features and Function of Multiple Evanescent White Dot Syndrome
Hangai et al.
Arch Ophthalmol 2009;127:1307-1313.
ABSTRACT | FULL TEXT  

Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome
Sikorski et al.
Br J Ophthalmol 2008;92:1552-1557.
ABSTRACT | FULL TEXT  

Integrity of foveal cones in multiple evanescent white dot syndrome assessed with OCT and foveal reflection analyser
Kanis and van Norren
Br J Ophthalmol 2006;90:795-796.
FULL TEXT  

Acute zonal occult outer retinopathy: towards a set of diagnostic criteria
Francis et al.
Br J Ophthalmol 2005;89:70-73.
ABSTRACT | FULL TEXT  

Multiple Evanescent White Dot Syndrome in a Patient With Best Disease
Park et al.
Arch Ophthalmol 1997;115:1342-1343.
 

Choroidopathy in Multiple Evanescent White Dot Syndrome
Borruat et al.
Arch Ophthalmol 1995;113:1569-1571.
ABSTRACT  

Subretinal Neovascularization Following Multiple Evanescent White-Dot Syndrome
Wyhinny et al.
Arch Ophthalmol 1990;108:1384-1385.
ABSTRACT  

Protracted Enlargement of the Blind Spot in Multiple Evanescent White Dot Syndrome
Hamed et al.
Arch Ophthalmol 1989;107:194-198.
ABSTRACT  

Multiple Evanescent White Dot Syndrome: I. Clinical Findings
Jampol et al.
Arch Ophthalmol 1984;102:671-674.
ABSTRACT