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I. Clinical Findings

Lee M. Jampol, MD; Paul A. Sieving, MD, PhD; David Pugh, MD; Gerald A. Fishman, MD; Howard Gilbert, MD

Arch Ophthalmol. 1984;102(5):671-674.

Abstract
• We examined 11 young patients with unilateral ocular findings that included multiple white dots at the level of the retinal pigment epithelium (RPE) or the deep retina, vitreal cells, RPE granularity in the macula, reduced visual acuity, electroretinogram (ERG) and early receptor potential (ERP) amplitudes, and fluorescein leakage from disc capillaries and late staining of the RPE. Recovery of visual function included a dramatic improvement in ERG and ERP amplitudes over several weeks. The etiology of this syndrome remains uncertain; there is no definite evidence of systemic involvement.

Author Affiliations
From the Departments of Ophthalmology, Northwestern University (Dr Jampol) and the University of Illinois Eye and Ear Infirmary (Drs Jampol, Sieving, Pugh, and Fishman) Chicago. Dr Sieving is currently with the Department of Ophthalmology, University of California, San Francisco.

Footnotes
Accepted for publication Nov 30, 1983.

Reprint requests to 303 E Chicago Ave, Chicago, IL 60611 (Dr Jampol).

This work was supported by grants from Fight for Sight, New York (Dr Sieving) and the National Retinitis Pigmentosa Foundation, Baltimore (Dr Fishman), and by core grant EY1792 and training grant EY7038 from the National Eye Institute to the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago.

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