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Henry J. Kaplan, MD; J. Clifford Waldrep, PhD; Janet K. A. Nicholson, PhD; David Gordon, MD

Arch Ophthalmol. 1984;102(4):572-575.

Abstract
• The pathogenesis of chronic idiopathic uveitis is not known. Analysis of inflammatory site (ie, intraocular) lymphocytes in the aqueous humor and/or vitreous cavity was performed with monoclonal antibodies and a cell sorter. The mononuclear cell population within the aqueous humor of eyes with acute idiopathic uveitis resembled that observed in the peripheral blood. In contrast, eyes with chronic idiopathic uveitis displayed a scarcity of T cells within the vitreous. Eyes with chronic uveitis of presumed infectious cause did not show similar changes. These observations are consistent with the hypothesis that intraocular T-cell immunoregulation of B-cell function may be defective in some stages of chronic idiopathic uveitis.

Author Affiliations
From the Departments of Ophthalmology (Drs Kaplan and Waldrep) and Medicine (Dr Gordon), Emory University; and the Centers for Disease Control (Dr Nicholson), Atlanta.

Footnotes
Accepted for publication Aug 29, 1983.

Read in part before the Third International Symposium on Immunology and Immunopathology of the Eye, Seattle, Oct 28, 1982.

Reprint requests to Department of Ophthalmology, Emory University Clinic, 1365 Clifton Rd NE, Atlanta, GA 30322 (Dr Kaplan).

This study was supported in part by National Institutes of Health grant EY03723, and in part by an unrestricted grant to the Department of Ophthalmology, Emory University, from Research to Prevent Blindness, Inc, New York.

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