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  Vol. 102 No. 4, April 1984 TABLE OF CONTENTS
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The Wisconsin Epidemiologic Study of Diabetic Retinopathy

III. Prevalence and Risk of Diabetic Retinopathy When Age at Diagnosis Is 30 or More Years

Ronald Klein, MD; Barbara E. K. Klein, MD; Scot E. Moss, MA; Matthew D. Davis, MD; David L. DeMets, PhD

Arch Ophthalmol. 1984;102(4):527-532.


Abstract



• In a population-based study in southern Wisconsin, 1,370 patients given diagnoses of diabetes at age 30 years or older were examined using standard protocols to determine the prevalence and severity of diabetic retinopathy and associated risk variables. The prevalence of diabetic retinopathy varied from 28.8% in persons who had diabetes for less than five years to 77.8% in persons who had diabetes for 15 or more years. The rate of proliferative diabetic retinopathy varied from 2.0% in persons who had diabetes for less than five years to 15.5% in persons who had diabetes for 15 or more years. By using the Cox regression model, the severity of retinopathy was found to be related to longer duration of diabetes, younger age at diagnosis, higher glycosylated hemoglobin levels, higher systolic BP, use of insulin, presence of proteinuria, and small body mass.



Author Affiliations



From the Departments of Ophthalmology (Drs R. Klein, B. Klein, and Davis and Mr Moss) and Statistics (Dr DeMets), University of Wisconsin Medical School, Madison.


Footnotes



Accepted for publication Sept 1, 1983.

Reprint requests to Department of Ophthalmology, Clinical Science Center, 600 Highland Ave, Madison, WI 53792 (Dr R. Klein).

This work was supported by grant EY03083 (Dr R. Klein) from the National Eye Institute. Determinations of glycosylated hemoglobin levels were performed in the Core Laboratory of the Clinical Nutrition Center with support from the US Public Health Service National Institutes of Health grant P30 AM AG 26659 (Earl Shrago, MD).



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