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Respirator Retina
Robert Y. Foos, MD;
Roy H. Rhodes, MD, PhD
Arch Ophthalmol. 1984;102(2):296-303.
Abstract
• Retinas from 14 comatose patients, who had been sustained with a respirator for one or more days before death, had selective characteristic alterations (ie, autophagy, cell swelling, and coagulation necrosis) of inner nuclear layer in a patchy pattern in posterior fundus. Bipolar cells were most often affected, but amacrine and horizontal cells also were substantially damaged. Cells of Müller and vascular cells were largely spared. These lesions are ascribed to oligemia (ischemia) since the inner nuclear layer is a microscopic vascular watershed (boundary zone) between the choroidal and retinal circulations.
Author Affiliations
From the Department of Pathology and the Jules Stein Eye Institute, UCLA School of Medicine (Dr Foos) and the Department of Pathology and Cajal Laboratory of Neuropathology, University of Southern California School of Medicine, Los Angeles (Dr Rhodes).
Footnotes
Accepted for publication Feb 14, 1983.
Read before the annual spring meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 5, 1982.
Reprint requests to Jules Stein Eye Institute, UCLA Center for the Health Sciences, Los Angeles, CA 90024 (Dr Foos).
This work was supported in part by Public Health Service Center grant EY 00331 and research grant EY 00725 from the National Eye Institute, by PHS training grants 5TI-GM 851 and NB 05891, and by Research Manpower Award from Research to Prevent Blindness, Inc, New York.
Kay Hollars and M. Change assisted with the manuscript, and Fred Hayes and D. Lew assisted with the illustrations.
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