Trilateral retinoblastoma. Report of two cases
S. Brownstein, J. P. de Chadarevian and J. M. Little
Two children had bilateral retinoblastoma and a morphologically similar
intracranial neoplasm localized to the region of the pineal gland as shown
on computed tomography and at postmortem examination. The first child's
intracranial malignant neoplasm produced symptoms that indicated its
probable presence when the ocular tumors were first diagnosed. With the
second child, there was a latent period of more than three years between
the diagnosis and initial management of the ocular neoplasms and the onset
of symptoms from the pineal tumor. We diagnosed both cases as trilateral
retinoblastoma, which in our experience is a relatively frequent cause of
mortality in patients with heritable retinoblastoma.
