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Prophylactic Topical Cyclosporine in Experimental Herpetic Stromal Keratitis
Hélène M. Boisjoly, MD;
John J. Woog, MD;
Deborah Pavan-Langston, MD;
No-Hee Park, DMD, PhD
Arch Ophthalmol. 1984;102(12):1804-1807.
Abstract
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• We determined the anti-inflammatory prophylactic effect of topical cyclosporine in a rabbit model of herpetic stromal keratitis. In a first study, we established that presensitization of rabbits prior to corneal intrastromal injection of herpes simplex virus produced a severe stromal keratitis beginning on day 7 after the intrastromal challenge. Twenty-four presensitized rabbits were thereafter divided into three groups for topical treatment five times a day: (1) 1% cyclosporine in a vehicle solution, started on day 4 after intrastromal challenge, plus 1% trifluridine started on day 7 after challenge, (2) the vehicle solution for cyclosporine, started on day 4, plus 1% trifluridine started on day 7, and (3) the vehicle solution for cyclosporine alone, started on day 4. The severity of stromal disease was significantly decreased in eyes treated with combined cyclosporine-trifluridine, whereas trifluridine alone had no effect on the stromal disease. Epithelial disease did not seem to be worse in eyes treated with combined cyclosporine-trifluridine; the incidence and duration of positive cultures, however, were increased in this group.
Author Affiliations
From the Eye Research Institute of Retina Foundation (Drs Boisjoly, Pavan-Langston, and Park); the Department of Ophthalmology, Harvard Medical School (Drs Boisjoly, Woog, and Pavan-Langston); the Laboratory of Virology and Chemotherapy, Harvard School of Dental Medicine (Dr Park), Boston.
Footnotes
Accepted for publication June 15, 1984.
Reprint requests to Department of Ophthalmology, Universite Laval, 2705 Blvd Laurier, Quebec, Canada G1V 4G2 (Dr Boisjoly).
This investigation was supported by a Centennial fellowship grant of the Medical Research Council of Canada (Dr Boisjoly), National Institutes of Health research grants EYNS-02268 (Dr Pavan-Langston), and NIDR-06435 (Dr Park), and a grant from the Prince Charitable Trust, Chicago (Dr Pavan-Langston). The herpes simplex virus type 1, RE strain, was obtained through the courtesy of C. R. Dawson, MD, from the Proctor Foundation, University of California, San Francisco. The cyclosporine powder was provided by Sandoz Pharmaceuticals, East Hanover, NJ.
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