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Alexander M. Walker, MD, DPH; Claudia Arrigg, MD; Ellen Hertzmark, MA; David L. Epstein, MD

Arch Ophthalmol. 1984;102(12):1785-1787.

Abstract
• The use of carbonic anhydrase inhibitors (CAIs) was associated with mean increases in whole-blood zinc levels of 82 µg/dL and 70 µg/dL, respectively, in a cross-sectional survey and in a prospective study of patients with glaucoma. The time course of the increase suggests that CAIs induce reticulocyte synthesis of carbonic anhydrase.

Author Affiliations
From the Department of Epidemiology, Harvard School of Public Health, Boston, and the Division of Epidemiology and Biostatistics, International Agency for Research on Cancer, Lyon, France (Dr Walker); and the Glaucoma Consultation Service and Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston (Drs Arrigg and Epstein and Ms Hertzmark).

Footnotes
Accepted for publication April 30, 1984.

Reprint requests to the Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02215 (Dr Walker).

This investigation was supported by National Eye Institute Research Grants EY01894 and GY00002.

Milos Chvapil, PhD, initially stimulated our interest in trace metals.

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