Multifocal Choroiditis and Panuveitis: A Syndrome That Mimics Ocular Histoplasmosis

doi:10.1001/archopht.1984.01040031440019

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Vol. 102 No. 12, December 1984

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Multifocal Choroiditis and Panuveitis

A Syndrome That Mimics Ocular Histoplasmosis

Richard F. Dreyer, MD; J. Donald M. Gass, MD

Arch Ophthalmol. 1984;102(12):1776-1784.

Abstract

• A review of 28 cases of multifocal choroiditis with vitreousinflammatory cells demonstrates that these patients have chorioretinalscars similar to those in the presumed ocular histoplasmosissyndrome (POHS), but they have a low incidence of positive histoplasminskin test reactions and calcified granulomata on chest x-rayfilms. Anterior chamber inflammation is a frequent finding.The epidemiologic background of these patients is differentfrom those with POHS. The subjects in this study were also differentfrom patients with birdshot or vitiliginous choroiditis andacute posterior multifocal placoid pigment epitheliopathy. However,unilateral cases are difficult to distinguish from cases ofdiffuse unilateral subacute neuroretinitis. While it is possiblethat a subretinal nematode may have caused some of the unilateralcases in this review, multiple causative agents are likely,including an unidentified agent that causes cross reactionsto histoplasmin skin tests.

Author Affiliations

From the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine.

Footnotes

Accepted for publication Aug 3, 1984.

Reprints not available.

This investigation was supported in part by Public Health Servicegrant EY02549, Department of Health and Human Services, NationalInstitutes of Health, National Eye Institute, Bethesda, Md,by the Walter G. Ross Foundation, Washington, DC, and by Researchto Prevent Blindness Inc, New York.

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