Multifocal choroiditis and panuveitis. A syndrome that mimics ocular histoplasmosis
R. F. Dreyer and D. J. Gass
A review of 28 cases of multifocal choroiditis with vitreous inflammatory
cells demonstrates that these patients have chorioretinal scars similar to
those in the presumed ocular histoplasmosis syndrome (POHS), but they have
a low incidence of positive histoplasmin skin test reactions and calcified
granulomata on chest x-ray films. Anterior chamber inflammation is a
frequent finding. The epidemiologic background of these patients is
different from those with POHS. The subjects in this study were also
different from patients with birdshot or vitiliginous choroiditis and acute
posterior multifocal placoid pigment epitheliopathy. However, unilateral
cases are difficult to distinguish from cases of diffuse unilateral
subacute neuroretinitis. While it is possible that a subretinal nematode
may have caused some of the unilateral cases in this review, multiple
causative agents are likely, including an unidentified agent that causes
cross reactions to histoplasmin skin tests.
