Coloboma of optic nerve associated with serous maculopathy. A clinicopathologic correlative study
C. C. Lin, M. O. Tso and C. M. Vygantas
A rhesus monkey with a congenital coloboma of the optic nerve head
associated with serous macular detachment underwent intravenous (IV),
intrathecal, and retrobulbar fluorescein angiography. No fluorescein leaked
beneath the serous detachment after IV or intrathecal injection, although
the retrobulbar injection caused a bolus to extravasate from the margin of
the optic nerve coloboma, drifting toward the macular region temporally.
Histopathologically, glial tissue replaced optic nerve axonal bundles in
the temporal coloboma. The intermediary tissue of Kuhnt was disrupted, and
fluid from the retrobulbar space diffused into the subretinal space
temporally, where a localized retinal detachment extended from the optic
nerve to the macula. Subretinal fluid in the macula associated with optic
nerve coloboma might derive from (1) fluid perfusing into the retrobulbar
space from surrounding orbital tissue, (2) peripapillary choriocapillaris,
or (3) CSF.
