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Bernard Jacobson, PhD; Prasanta K. Basu, MB, DOMS; Syed M. Hasany, MSc

Arch Ophthalmol. 1984;102(10):1543-1545.

Abstract
• Normal and pathologic human vitreous have been analyzed for the presence of a low—molecular weight inhibitor of aortic endothelial cell proliferation. Vitreous was subjected to gel chromatography and the material appearing in the retarded volume (<13,000 daltons) was tested for its ability to inhibit tritiated thymidine incorporation into DNA by calf aortic endothelial cells. Depending on the sample of vitreous analyzed, one or more fractions showing inhibitory activity were identified in each case.

Author Affiliations
From the Department of Fine Structure Research, Boston Biomedical Research Institute, and the Department of Ophthalmology, Harvard Medical School, Boston (Dr Jacobson), and the Department of Ophthalmology, University of Toronto (Dr Basu and Mr Hasany).

Footnotes
Accepted for publication May 11, 1984.

Reprint requests to Department of Fine Structure Research, Boston Biomedical Research Institute, 20 Staniford St, Boston, MA 02114 (Dr Jacobson).

This study was supported by National Institutes of Health grant EY-04393 (Dr Jacobson) and the Lions International District A-16 Ophthalmological Research Foundation, The Canadian National Institute for the Blind out of the E. A. Baker Foundation for the Prevention of Blindness, and the Medical Research Council of Canada, Toronto (Dr Basu).

C. Mortimer, MD, M. Mandelcorn, MD, and M. Shusterman, MD, supplied the vitrectomy samples, and the Eye Bank of Canada, Ontario, supplied the cadaver vitreous. Margaret O'Neil performed the gel chromatography and testing of vitreous fractions on endothelial cell growth.

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