Effect of topical timolol maleate on exercise performance
W. J. Doyle, P. A. Weber and R. H. Meeks
The effect of topical timolol maleate on exercise performance was
investigated in a randomized double-blind study. Healthy young subjects
underwent two graded maximal exercise evaluations on a treadmill. The
evaluations were given one week apart. Before each trial, the subjects were
given a single drop of either placebo or 0.5% timolol maleate in each eye.
The results indicate that topical timolol has a statistically significant
effect on both maximal heart rate and time to exhaustion. However, we found
that the drug had no effect on the physiologic parameters of Vo2,
respiratory rate, Vco2, or respiratory quotient.
